ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Large T antigen

Intermolecular
Cysteine 105 and cysteine 706 of Retinoblastoma-associated protein
A redox-regulated disulphide may form between cysteine 105 of Large T antigen and cysteine 706 of Retinoblastoma-associated protein. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
1gh6
Structure name
retinoblastoma pocket complexed with sv40 large t antigen
Structure deposition date
2000-11-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
10
% buried
78
Peptide A name
Large T antigen
Peptide B name
Retinoblastoma-associated protein
Peptide A accession
P03070
Peptide B accession
P06400
Peptide A residue number
105
Peptide B residue number
706

Ligandability

Cysteine 105 of Large T antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 706 of Retinoblastoma-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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